According to a press release by the Tucson Police Department the 71-year-old male was attempting to ride south across Kolb Road when he was struck by a driver heading west on Golf Links Road.
The cyclist was taken to a hospital where he later died.
The driver stayed at the scene and drugs and alcohol did not appear to be a contributing factor.
No details about speed were provided. The bicyclist was not wearing a helmet.
The cyclist was the second bicyclist killed in Tucson this year and matches the number of cyclists killed in 2012.